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2016年

 ●  2016年代表性论文  

2016年药学院在聚焦重大前沿科学问题、引领科学发展方面取得了系统性原创成果,在药学相关领域公认的重要期刊上发表了200余篇高水平学术论文。一系列重要科研成果发表于Science, J. Am. Chem. Soc., J. Med. Chem., Eur. J .Med. Chem., J. Nat. Prod., Angew. Chem. Int. Ed., Biomaterials等高水平专业期刊。  

本年度全院共发表论文374篇(SCI收录256篇),会议报告论文110余篇。国内论文119篇,核心期刊收录98篇。国外论文255篇,SCI收录253篇;其中我院为第一完成单位发表的论文192篇,研究文章186篇,综述6篇。影响因子10以上的有10篇,7.0~10.0有11篇,4.0~7.0有47篇。

周德敏/张礼和课题组题为“Generation of Influenza A Viruses as Live but Replication-Incompetent Virus Vaccines” (制备复制缺陷的活流感病毒疫苗)的突破性研究进展发表在国际顶级期刊Science杂志上(IF34.66),鉴于该成果在预防和治疗病毒性传染病方面的重大医学价值和社会意义,全球最大的科技新闻工作站SciPak将该发现作为亮点,于美国东部时间12月1日下午2:00向全球媒体发布。随即新华社、纽约时报、华尔街日报、加拿大广播公司和香港南华早报等媒体相继跟进,对这一重大发现进行了专题报道。Nature杂志也对此突破性进展给与了高度评价,认为周德敏及其北京大学同仁们建立的方法将被广泛用来制备更高效的病毒疫苗。

焦宁教授研究团队在简洁高效合成邻苯二酚类活性分子方面取得重要进展、董甦伟教授课题组在基于脯氨酸硫酯的多肽连接方法研究中取得进展、张亮仁/张礼和研究团队发现钙信号通路新型调控蛋白,研究成果发表于J. Am. Chem. Soc. (IF13.04);叶新山研究团队在脲催化的立体选择性Koenigs-Knorr糖基化研究中取得进展,研究成果发表于Angew. Chem. Int. Ed.,IF11.71;焦宁教授课题组还在Chemical Society Reviews杂志上发表了1篇综述,影响因子34.09。

 ●  2016年影响因子6以上的文章目录        


序号

论文题目

杂志名称

 

SCI影响因子

1

Generation of influenza A viruses as live but replication-incompetent virus vaccines

Science

Longlong Si*, Huan Xu*, Xueying Zhou, Ziwei Zhang, Zhenyu Tian, Yan Wang, Yiming Wu, Bo Zhang,zhenlan Niu, Chuanling Zhang, Ge Fu, Sulong Xiao, Qing Xia, Lihe Zhang, Demin Zhou+

34.661

2

Ag-catalyzed C-H/C-C bond functionalization.

Chemical Society Reviews

Qing-Zhong Zheng, Ning Jiao

34.09

3

Internal Activation of Peptidyl Prolyl Thioesters in Native Chemical Ligation

J. Am. Chem. Soc.

Yue Gui, Lingqi Qiu, Yaohao Li, Hongxing Li, Suwei Dong

13.038

4

Direct Tryptophols Synthesis from 2-Vinylanilines and Alkynes via C≡C Triple Bond Cleavage and Dioxygen Activation.

Journal of the American Chemical Society

Shen, Tao; Zhang, Yiqun; Liang, Yu-Feng; Jiao, Ning

13.038

5

Conversion of Simple Cyclohexanones into Catechols.

Journal of the American Chemical Society

Liang, Yu-Feng; Li, Xinyao; Wang, Xiaoyang; Zou, Miancheng; Tang, Conghui; Liang, Yujie; Song, Song; Jiao, Ning

13.038

6

Novel Biological Functions of ZIF-NP as a Delivery Vehicle: High Pulmonary Accumulation, Favorable Biocompatibility, and Improved Therapeutic Outcome

ADVANCED FUNCTIONAL MATERIALS

Li Suxin, Wang Keke, Shi Yujie, Cui Yanan, Chen Binlong, He Bing, Dai Wenbing, Zhang Hua, Wang Xueqing, Zhong Chongli, Wu Hounan, Yang Qingyuan, Zhang Qiang*

11.805

7

Stereoselective Koenigs–Knorr Glycosylation Catalyzed by Urea

Angew. Chem. Int. Ed

Lifeng Sun, Xiaowei Wu, De-Cai Xiong, and Xin-Shan Ye

11.709

8

Photochemical Regulation of Gene Expression Using Caged siRNAs with Single Terminal Vitamin E Modification

Angew. Chem. Int. Ed.

Yuzhuo Ji, Jiali Yang, Li Wu, Lijia Yu, Xinjing Tang

11.709

9

Cationic Cobalt(III) Catalyzed Indole Synthesis: The Regioselective Intermolecular Cyclization of N-Nitrosoanilines and Alkynes.

Angewandte Chemie, International Edition

Liang, Yujie; Jiao, Ning.

11.709

10

Splitting a Substrate into Three Parts: Gold-Catalyzed Nitrogenation of Alkynes by C-C and C≡C Bond Cleavage.

Angewandte Chemie, International Edition

Chong Qin, Yijin Su, Tao Shen, Xiaodong Shi, Ning Jiao

11.709

11

Silver-Catalyzed Radical Transformation of Aliphatic Carboxylic Acids to Oxime Ethers.

ACS Catalysis

Zhu, Yuchao; Wen, Xiaojin; Song, Song; Jiao, Ning

9.307

12

Pd-catalyzed dehydrogenative annulation approach for the efficient synthesis of phenanthridinones.

Chemical Science

Li, Xinyao; Pan, Jun; Song, Song; Jiao, Ning

9.144

13

The modulation of tumor vessel permeability by thalidomide and its impacts on different types of targeted drug delivery systems in a sarcoma mouse model

Journal of Controlled Release

Dan Wang, Jijun Fu, Yujie Shi, Dong Peng, Lan Yuan, Bing He, Wenbing Dai, Hua Zhang , XueqingWang, Jie Tian, Qiang Zhang

8.8

14

Mechanistic study of the roles of disulfide-bridge in H-shape gemini-like cationic lipid based siRNA delivery

J. Control. Release

XF Ma, J Sun, YF Wu, Y Zheng, MZ Yu,  C Qiu, XW  Pei, L Wei,   YL Niu, WH Pang, Z.J.*; Yang, JC Wang,* Q Zhang

8.407

15

Pentacyclic triterpenes grafted on CD cores to interfere with influenza virus entry: A dramatic multivalent effect.

Biomaterials

Sulong Xiao, Longlong Si, Zhenyu Tian, Pingxuan Jiao, Zibo Fan, Kun Meng, Xiaoshu Zhou, Han Wang, Renyang Xu, Xu Han, Ge Fu, Yongmin Zhang, Lihe Zhang, Demin Zhou

8.387

16

Development of next generation adeno-associated viral vectors capable of selective tropism and efficient gene delivery.

Biomaterials

Zhang C, Yao T, Zheng Y, Li Z, Zhang Q, Zhang L, Zhou D

8.387

17

Systemic delivery of siRNA by hyaluronan-functionalized calcium phosphate nanoparticles for tumor-targeted therapy.

 Nanoscale.

Qiu C, Wei W, Sun J, Zhang HT, Ding JS, Wang JC*, Zhang Q

7.76

18

The modulation of tumor vessel permeability by thalidomide and its impacts on different types of targeted drug delivery systems in a sarcoma mouse model

J Control Release

Wang Dan#, Fu Jijun#, Shi Yujie, Peng Dong, Yuan Lan, He Bing, Dai Wenbing, Zhang Hua, Wang Xueqing, Tian Jie, Zhang Qiang*

7.705

19

Comprehensively priming the tumor microenvironment by cancer-associated fibroblast-targeted liposomes for combined therapy with cancer cell-targeted chemotherapeutic drug delivery system

J Control Release

Chen B, Dai W, Mei D, Liu T, Li S, He B, He B, Yuan L, Zhang H, Wang X, Zhang Q

7.705

20

Tumor-specific pH-responsive peptide-modified pH-sensitive liposomes containing doxorubicin for enhancing glioma targeting and anti-tumor activity.

J Control Release.

Zhao Y, Ren W, Zhong T, Zhang S, Huang D, Guo Y, Yao X, Wang C, Zhang WQ, Zhang X*, Zhang Q

7.441

21

The role of disulfide-bridge on the activities of H-shape gemini-like cationic lipid based siRNA delivery.

J Control Release.

Ma XF, Sun J, Qiu C, Wu YF, Zheng Y, Yu MZ, Pei XW, Wei L, Niu YJ, Pang WH, Yang ZJ*, Wang JC*, Zhang Q

7.44

22

Dynamic bio-adhesion of polymer nanoparticles on MDCK epithelial cells and its impact on bio-membranes, endocytosis and paracytosis

Nanoscale

He Bing, Yuan Lan, Dai Wenbing, Gao Wei, Zhang Hua, Wang Xueqing, Fang Weigang*, Zhang Qiang*

7.394

23

A comparative investigation between paclitaxel nanoparticle- and nanocrystal-loaded thermosensitive PECT hydrogels for peri-tumoural administration

Nanoscale

Lin Zhiqiang, Xu Suxin, Gao Wei, Hu Hongxiang, Chen Meiwan, Wang Yitao, He Bing, Dai Wenbing, Zhang Hua, Wang Xueqing, Dong Anjie*, Yin Yuxin*, Zhang Qiang*

7.394

24

Ligand-Controlled Monoselective C-Aryl Glycoside Synthesis via Palladium-Catalyzed C-H Functionalization of N-Quinolyl Benzamides with 1-Iodoglycals

Org. Lett

Minglong Liu, Youhong Niu, Yan-Fen Wu,* and Xin-Shan Ye

6.732

25

Diasteltoxins A-C, Asteltoxin-Based Dimers from a Mutant of the Sponge-Associated Emericella variecolor Fungus

Org. Lett.

Long, Hailin; Cheng, Zhongbin; Huang, Wei; Wu, Qi; Li, Xiaodan; Cui, Jingrong; Proksch, Peter; Lin, Wenhan

6.732

26

Dioxygen-Promoted Pd-Catalyzed Aminocarbonylation of Organoboronic Acids with Amines and CO: A Direct Approach to Tertiary Amides.

Organic Letters

Ren, Long; Li, Xinwei; Jiao, Ning

6.732

27

Rh-Catalyzed N-O Bond Cleavage of Anthranil: A C-H Amination Reagent for Simultaneous Incorporation of Amine and a Functional Group.

Organic Letters

Miancheng Zou Jianzhong Liu, Conghui Tang, Ning Jiao

6.732

28

Rh- and Cu-Cocatalyzed Aerobic Oxidative Approach to Quinazolines via [4 + 2] C-H Annulation with Alkyl Azides

Organic Letters

Wang, Xiaoyang; Jiao, Ning

6.732

29

NHPI and palladium cocatalyzed aerobic oxidativeacylation of arenes through a radical process.

Chem. Commun

Yu-Feng Liang, Xiaoyang Wang, Conghui Tang, Tao Shen, Jianzhong Liu, Ning Jiao

6.567

30

A palladium-catalyzed intramolecular carbonylative annulation reaction to form 4,5-fused tricyclic 2-quinolones

Chem. Commun.

Xiwu Zhang, Haichao Liu, Yanxing Jia

6.567

31

A concise gram-scale synthesis of ht-13-A via a rhodium-catalyzed intramolecular C–H activation reaction

Chem. Commun.

Pengyu Tao, Zhuang Chen, Yanxing Jia

6.567