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叶新山

叶新山

博士教授长江学者、国家杰出青年基金获得者、973首席

有机化学,药物化学,化学糖生物学

电话 & 传真: +86-10-82805736

联系邮箱: xinshan@bjmu.edu.cn


 

 

学习经历:

1981-1985           学士,武汉大学化学系

1985-1988           硕士,武汉大学化学系

1993-1996           博士,香港中文大学化学系

1996-2000           博士后,美国Scripps研究所

 

任职:

1988-1993          讲师,华中农业大学

2000-                  教授,北京大学

 

教学:               高等有机化学

 

研究方向与兴趣

1)新的寡糖化学合成的方法和策略的发展;

2)生物活性寡糖(包括肿瘤相关糖抗原)的合成及活性评价;

3)氨基糖苷类抗生素的化学改造;

4)糖苷酶、糖基转移酶抑制剂的设计、合成、评价以及基于糖类的新药的发现。

 

主要学术兼职:

中国化学会化学生物学专业委员会委员,中国生物工程学会糖工程专业委员会委员,中国生物化学与分子生物学会复合糖专业委员会副主任委员,国家重大新药创制科技重大专项总体专家组成员。担任《有机化学》、《高等学校化学学报》、《中国药物化学杂志》、《中国新药杂志》、《北京大学学报(自然科学版)》等杂志的编委,担任《Journal of Chinese Pharmaceutical Sciences》杂志的副主编,担任国际杂志Carbohydrate Research的编委。

 

代表性论文:

1.        Xuefei Huang, Lijun Huang, Haisheng Wang, Xin-Shan Ye, “Iterative one-pot synthesis of oligosaccharides”, Angew. Chem. Int. Ed., 2004, 43, 5221-5224.

2.        Haisheng Wang, Ji She, Li-He Zhang, Xin-Shan Ye, “Silver(I) oxide mediated selective monoprotection of diols in pyranosides”, J. Org. Chem., 2004, 69, 5774-5777.

3.        Yuhang Wang, Xuefei Huang,  Li-He Zhang, Xin-Shan Ye, “A four-component one-pot synthesis of α-Gal pentasaccharide”, Org. Lett., 2004, 6, 4415-4417.

4.        Yuan Wang, Qin Li, Shuihong Cheng, Yanfen Wu, Dongjie Guo, Qiu-Hua Fan, Xiaofang Wang, Li-He Zhang, Xin-Shan Ye, “Base-Promoted Rearrangement of Sugar Epoxides to Unsaturated Sugars”, Org. Lett. 2005, 7, 5577-5579.

5.        Xin-Shan Ye, Fang Sun, Min Liu, Qin Li, Yuhang Wang, Guisheng Zhang, Li-He Zhang, Xiao-Lian Zhang, “Synthetic iminosugar derivatives as new potential immunosuppressive agents”, J. Med. Chem., 2005, 48, 3688-3691.

6.        Qiu-Hua Fan, Nan-Ting Ni, Qin Li, Li-He Zhang, Xin-Shan Ye, “New One-Carbon Degradative Transformation of -Alkyl--azido Alcohols”, Org. Lett. 2006, 8, 1007-1009.

7.        Jian Zhou, Guannan Wang, Li-He Zhang, Xin-Shan Ye, “Modifications of Aminoglycoside Antibiotics Targeting RNA”, Med. Res. Rev., 2007, 27, 279-316.

8.        Yiqun Geng, Li-He Zhang, Xin-Shan Ye“Pre-activation protocol leading to highly stereoselectivity-controllable glycosylations of oxazolidinone protected glucosamine donors”, Chem. Commun., 2008, 597-599.

9.        De-Cai Xiong, Li-He Zhang, and Xin-Shan Ye*, “Bromodimethylsulfonium bromide-silver triflate: a new powerful promoter system for the activation of thioglycosides”, Adv. Synth. Catal. 2008, 350, 1696-1700.

10.    Yin-Suo Lu, Qin Li, Li-He Zhang, and Xin-Shan Ye*, “Highly Direct α-Selective Glycosylations of 3,4-O-Carbonate-Protected 2-Deoxy and 2,6-Dideoxythioglycosides by Preactivation Protocol”, Org. Lett. 2008, 10, 3445-3448.

11.    Guan-Nan Wang, Gabriele Reinkensmeier, Siwei Zhang, Jian Zhou, Liangren Zhang, Li-He Zhang, Terry D. Butters* and Xin-Shan Ye*, “Rational Design and Synthesis of Highly Potent Pharmacological Chaperones for Treatment of N370S Mutant Gaucher Disease”, J. Med. Chem., 2009, 52, 3146-3149.

12.    De-Cai Xiong, Li-He Zhang, and Xin-Shan Ye*, “Oxidant-Controlled Heck-Type C-Glycosylation of Glycals with Arylboronic Acids: Stereoselective Synthesis of Aryl 2-Deoxy-C-Glycosides”, Org. Lett., 2009, 11, 1709-1712.

13.    Lin Yang and Xin-Shan Ye*, “Development of Aminoglycoside Antibiotics Effective Against Resistant Bacterial Strains”, Curr. Top. Med. Chem., 2010, 10, 1898-1926.

14.    Fan Yang, Xiu-Jing Zheng, Chang-Xin Huo, Yue Wang, Ye Zhang*, and Xin-Shan Ye*, “Enhancement of the immunogenicity of synthetic carbohydrate vaccines by chemical modifications of STn antigen”, ACS Chem. Biol., 2011, 6, 252-259.

15.    Guan-Nan Wang, Lin Yang, Li-He Zhang, and Xin-Shan Ye*, “A Versatile Approach to N-Alkylated 1,4-Dideoxy-1,4-Imino-D-Arabinitols and 1,4-Dideoxy-1,4-Imino-L-Xylitols”, J. Org. Chem., 2011, 76, 2001-2009.

16.    Guan-Nan Wang, Yulan Xiong, Jia Ye, Li-He Zhang, and Xin-Shan Ye*, “Synthetic N-Alkylated Iminosugars as New Potential Immunosuppressive Agents”, ACS Med. Chem. Lett. 2011, 2, 682-686.

 

 

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